Reproduction Abstracts

Introduction: Since progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 are highly expressed in the uterus, this study was designed to evaluate the impact of Pgrmc2 and Pgrmc1/2 deficiency on female fertility and uterine epithelial cell proliferation.Materials and methods: Uterine PGRMC2 and Ki67 expression were assessed by immunohistochemistry. Mutagenesis studies were completed in which Pgr-cre was used to conditio...

Introduction: Previous studies suggest that progesterone receptor membrane component 1 (PGRMC1) plays an essential role during bovine oocyte meiosis, since it i) localizes to the centromeres at metaphases I and II and ii) concentrates between the separating chromosomes at ana/telophase I. Moreover, injection of an antibody to PGRMC1 significantly impairs completion of meiosis. The aim of the present study is to expand these findings by using siRNA (RNAi)-mediated gene silencin...